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Warning signs include dark urine, reduced urine output, dizziness, confusion, or inability to keep down fluids for more than 24 hours

doi: 10.1016/S0140-6736(12)61425-1

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2026 Jan 23

A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients

In the HG-induced transfection of PINK1 siRNA in HK-2 cell model and HFD/STZ induced DKD rats model induced by HFD/STZ, a novel aldose reductase inhibitor (WJ-39) was found to inhibit aldose reductase activity, activate the PINK1/Parkin signaling pathway, promote mitophagy, and alleviate cell apoptosis, thereby exerting a certain therapeutic effect on DKD and inhibiting renal fibrosis [137]